Sure it will handle the pressure but will it stand up to the additives in the stuff they call gas now days.  I used the nyion fuel line that they use on the newer cars now .

Sure, JIC fittings would work just fine and are used in fuel systems all the time.  Basically its just a 37 degree flare with a metal to metal seal.  JIC fittings are essentially identical to AN fittings, but are made to somewhat less precise tolerances, and this are typically less costly.  This tolerance difference is a difference between two different MIL specs, and I wouldn't by any means construe that to mean the JIC fittings are no well suited for anything automotive.  AN fittings are MIL spec'd for aeronautical use, and as such the tolerances are more extreme because if something fails 1,000 feet under water on a sub, or 35,000 feet above the earth at Mach 2 on an airplane things tend to go horribly, horribly wrong in a matter of nanoseconds.  We always used to say a part for a car cost X, the same part for a boat costs 2X, and the same part for an airplane cost 10X.  Regulations compliance much more than tolerance is the main reason why those boat and aircraft parts cost more. 
 

Aluminum does work harden like copper.  Its that work hardening that causes cracks; the metal stops being malleable and fails.

However, the aluminum fuel line is very soft, I'm certain that its not a heat treated variety of aluminum, and in fact has likely been annealed to make it soft and easy to bend. 

In actual use I don't see the fuel lines bending and flexing enough to make work hardening an issue.  You would have to loosen and tighten the same fitting a lot before work hardening would become an issue. 

I'm currently running an aluminum line from the mechanical pump to the fuel filter.  Its only been on the car a short while, but so far so good.  I got sick to the total PITA of bending 3/8" steel line.  I made two previous lines from steel that I had to change due to my Borgeson steering conversion (pump was in the way), and when I installed my Edelbrock carb.  Once the lines were made there was no modifying them in any substantial way.  Getting the number of bends I needed in close proximity was extremely difficult, as is flaring tubing that big.  The aluminum line was a joy to work with in comparison.  Bent easily, was easily tweaked as needed on installation, and flared easily with standard tools.  Also, NO LEAKS.  The steel line it replaced would every once in a while dribble one or two drops of fuel at the connection to the pump.  I tried almost everything to remedy it to no avail (I think it was the flare being slightly wonky due to how much force is required to get the flare started on tubing that big).  The aluminum line does not have this issue.  I'm quite happy with it.  Of course like all new things I try I will keep a close eye on it, but I've put about 300 miles on the car since its installation and thus far its performed flawlessly. 

I figure I am only running less than 10' of line, 5 clamps should hold it pretty solid. I am not too worried about the additives in the gas, because if you run steel lines they would also be eaten up. The only thing I don't know about is the galvanic corrosion between aluminum line and the fittings. I may just run the steel lines and forget about it.
 

I installed Alum fuel line BEFORE the second MSBB(ever how long ago that was).
No Prob!!
I ran the line INSIDE a 3/8th's (I think) pneumatic air hose I had laying around. Really makes kink free bends EZ and....also gives protection from flying rocks and small animals!
Haven't seen any delitorious  effects from this gas-a-hole we use for fuel!
6s6 

If using compression fittings make sure you use stainless ones meant for hydraulic assemblies.  The typical plumbing compression fittings sold at Home Depot, etc. will eventually leak because they are designed to hold water not fuel.  Fuel is considerably thinner than water and doesn't have the advantage of cohesion.  There are compression fittings sold at the auto parts stores, but those are not meant for stainless lines, so I would question their ability to work properly on something as hard as stainless.  Any shop that makes hydraulic hoses should have the right fittings.  A few dollars more, but infinitely more peace of mind. 

We used Exploder rails on the Falcon project (left rear connections).  I thought they were going to be a PITA but they actually worked out very nice and easier than running the second fuel line to the front of the engine...as I did on the Heap.